Latest Inventions Health care Surgery METHOD OF PRESERVATION AND STERILISATION OF BIOLOGICAL PROSTHESES FOR CARDIOVASCULAR SURGERY.|
METHOD OF PRESERVATION AND STERILISATION OF BIOLOGICAL
PROSTHESES FOR CARDIOVASCULAR SURGERY.
SUBSTANCE: invention concerns medicine area, namely to cardiovascular surgery,
and can be used at preservation and biomaterial sterilisation, in particular at
manufacturing of heart valve prostheses, vessels. The way of preservation and
sterilisation of biological prostheses is performed in the diglycidyl ether
solution at temperature of 5-25C within 2-21 days, prepared on 0.05-0.1 M of
the phosphate-tetraborate buffer (pH 7.4) with addition of 1-15% ethyl alcohol.
The osmolarity of the 0.05-0.1 M phosphatetetraborate buffer is close to
parametres of blood and keeps stable pH of the solution.
Addition of 1-15% ethyl alcohol allows to lower rate of diglycidyl ether
decomposing at storage.
EFFECT: invention allows raising durability and elasticity of a biotissue, to
strengthen sterilising effect of a preserving solution, to
enlarge the period from the moment of a native tissue acquisition before bracing
of a biological prosthesis. 2 tbl.
Publishing date: April 8, 2009
Inventor(s): Zhuravleva Irina Jur’evna (RU),
Barbarash Leonid Semenovich (RU), Kudrjavtseva Julija Aleksandrovna (RU),
Gantimurova Irina Leonidovna (RU), Levanova Rajma Khajdargaleevna (RU)
Patent ¹ 2350075
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