Scientific News Health care Surgery Ingredient Found In Green Tea Significantly Inhibits Breast. Cancer Growth In Female Mice.|
Ingredient Found In Green Tea
Significantly Inhibits Breast.
Cancer Growth In Female Mice.
Green tea is high in the
antioxidant EGCG (epigallocatechin-3- gallate) which helps prevent the body’s
cells from becoming damaged and prematurely aged. Studies have suggested that
the combination of green tea and EGCG may also be beneficial by providing
protection against certain types of cancers, including breast cancer. A new
study conducted by researchers at the University of Mississippi researchers now
finds that consuming EGCG significantly inhibits breast tumor growth in female
mice. These results bring us one step closer to better understanding the disease
and potentially new and naturally occurring therapies.
The study was conducted by Jian-Wei Gu, Emily
Young, Jordan Covington, James Wes Johnson, and Wei Tan, all of the Department
of Physiology & Biophysics, University of Mississippi Medical Center,
Jackson, MS. Dr. Gu will present his team’s findings, entitled, Oral
Administration of EGCG, an Antioxidant Found in Green Tea, Inhibits Tumor
Angiogenesis and Growth of Breast Cancer in Female Mice, at the 121st
Annual Meeting of the American Physiological Society (APS; www.the-APS.org/press),
part of the Experimental Biology 2008 scientific conference.
Epidemiological studies suggest
that green tea and its major constituent, EGCG, can provide some protection
against cancer. Because these studies were very limited, the anti-cancer
mechanism of green tea and EGCG was not clear. As a result, the researchers
examined whether drinking EGCG (just the antioxidant infused in water) inhibited
the following: expression of VEGF (vascular endothelial growth factor, which is
found in a variety of breast cancer types); tumor angiogenesis (thought to help
tumors expand by supplying them with nutrients); and the growth of breast cancer
in female mice.
Seven week old female mice were given EGCG (25 mg/50
ml) in drinking water for five weeks (approximately 50-100 mg/kg/day.) The
control mice received regular drinking water. In the second week of the study
mouse breast cancer cells were injected in the left fourth mammary glands of the
mice. Tumor size was monitored by measuring the tumor cross section area (TCSA).
Tumors were eventually isolated and measured for tumor weight, intratumoral
microvessel (IM) density (using staining), and VEGF protein levels (using ELISA).
At the end of the five week period the
researchers found that oral consumption of EGCG caused significant
decreases in TCSA (66%), tumor weight (68%), IM density 155±6 vs.111±20 IM#mm^2)
and VEGF protein levels (59.0±3.7 vs. 45.7±1.4 pg/mg) in the breast
tumors vs. the control mice, respectively (N=8; P<0.01). Further, VEGF
plasma levels were lower in EGCG mice than in control mice (40.8±3.5 vs. 26.5±3.8
pg/ml P< 0.01).
Dr. Gu, the senior researcher for the study,
hypothesized that the reason for the link between EGCG and the reductions in the
cancer data was because EGCG directly targets both tumor blood vessels and tumor
cells of breast cancer for suppressing the new blood vessels formation in breast
tumor, the proliferation and migration of breast cancer cells.
Gu concluded by saying, “In this study we have
demonstrated that the frequent ingestion of EGCG significantly inhibits breast
tumor growth, VEGF expression and tumor angiogenesis in mice. We believe our
findings will help lead to new therapies for the prevention and treatment of
breast cancer in women.”
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Publishing date: April 21, 2008
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