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Scientific News Health care Oncology CANCER DIAGNOSED IN 70 MILLION-YEAR-OLD
CANCER DIAGNOSED IN 70 MILLION-YEAR-OLD
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A brain tumour would have
affected a dinosaur's balance and ability to move about. (Reuters) |
The first discovery of a brain tumour in a
dinosaur has revealed that they are indistinguishable from human tumours,
suggesting the global disease has barely changed over 70 million years.
The new evidence was announced by researchers from the Black
Hills Institute of Geological Research in South
Dakota to a conference of the Society of Vertebrate Palaeontology in Minneapolis.
In related research, Bruce Rothschild and colleagues from the
Northeastern Ohio Universities College of Medicine
have published evidence of tailbone tumours in duck-billed dinosaurs, in the
journal Naturwissenschaften.
Both types of tumours were found in bones from around 70 million years ago, and
suggest tumours have remained unchanged since ancient times.
A thumb-sized brain tumour in the mighty meat eater, Gorgosaurus, a
cousin of the infamous Tyrannosaurus Rex, must have caused a bad headache
that left the 7.5m long giant stumbling for balance.
Black Hills Institute president Peter Larson discovered the mass inside the
brain-case of an exhibit. He describes it as "very bizarre, dark material
in the matrix that looks kind of like crumpled paper".
"I broke off a little piece and put it in a scanning electron microscope
and basically bombarded it with X-rays to tell what sort of elements were there,"
says Larson.
Larson was unable to conclude if the brain tumour was the cause of death,
however, "it almost certainly affected its balance and locomotor function,"
says Rachel Reams, a veterinary pathologist who examined the brain case.
In a much broader study, Bruce Rothschild and team used X-ray techniques to scan
10,000 dinosaur vertebrae from 700 museum specimens, ranging from Tyrannosaurus
to Triceratops. The team found tumours only in hadrosaurs, or duck-billed
dinosaurs, of which 97 individuals had tumours.
Most were tumours of the blood vessels, which are also present in one out of ten
humans.
The results are significant in that the tumours found in the dinosaurs were
identical to human tumours, suggesting that cancer has been around relatively
unchanged for up to 100 million years.
"Diseases look the same independent of what critter is affected," says
Rothschild. "If I showed [the dinosaur bones] to a pathologist, he'd make
the same diagnosis."
Professor Mike Archer, Director of the Australian
Museum finds the results extremely significant.
"They [dinosaurs] suffered like animals do today with the same diseases,
and just like us they often get taken out by them," he told ABC Science
Online.
"This technology for the first time enables palaeontologists to look inside
bones. These are incredible tools that until now weren't available."
Tumours in dinosaurs have been found previously but this is the largest scale
study done so far and suggests that there was a much higher incidence of cancer
than previously thought. It is unclear why the tumours were confined to one
group of dinosaurs - it may be either genetic or environmental factors, he says.
Although the researchers suggest that conifers which made up their diet may have
been high in carcinogenic chemicals, Archer thinks that this is unlikely. Cycads,
another favourite dinosaur food, is a more likely culprit, Archer says.
"Cycads contain some of the most powerful carcinogens known to mankind.
There's a lot of food value in the cycads, you can't blame the dinosaurs for
having a munch, but it's not only a powerful carcinogen, it makes you violently
ill."
"Understanding what causes tumours in wild and extinct animals might help
treat and prevent them in humans," says Rothschild.
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Publishing date: November 4, 2003
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